This gelsolin-like domain is found in a group of uncharacterised fungal proteins. Its function is unknown.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00030660":{"PMID":15215896,"ISBN":null,"volume":"23","issue":"14","year":2004,"title":"Structure of the N-terminal half of gelsolin bound to actin: roles in severing, apoptosis and FAF.","URL":null,"raw_pages":"2713-22","medline_journal":"EMBO J","ISO_journal":"EMBO J.","authors":["Burtnick LD","Urosev D","Irobi E","Narayan K","Robinson RC."],"DOI_URL":"http://dx.doi.org/10.1038/sj.emboj.7600280"},"PUB00040658":{"PMID":16469333,"ISBN":null,"volume":"357","issue":"3","year":2006,"title":"The structure of gelsolin bound to ATP.","URL":null,"raw_pages":"765-72","medline_journal":"J Mol Biol","ISO_journal":"J. Mol. Biol.","authors":["Urosev D","Ma Q","Tan AL","Robinson RC","Burtnick LD."],"DOI_URL":"http://dx.doi.org/10.1016/j.jmb.2006.01.027"},"PUB00029181":{"PMID":12742020,"ISBN":null,"volume":"329","issue":"1","year":2003,"title":"Gelsolin domains 4-6 in active, actin-free conformation identifies sites of regulatory calcium ions.","URL":null,"raw_pages":"85-92","medline_journal":"J Mol Biol","ISO_journal":"J. Mol. Biol.","authors":["Kolappan S","Gooch JT","Weeds AG","McLaughlin PJ."],"DOI_URL":"http://dx.doi.org/10.1016/S0022-2836(03)00383-8"},"PUB00025486":{"PMID":12460571,"ISBN":null,"volume":"324","issue":"4","year":2002,"title":"The calcium activation of gelsolin: insights from the 3A structure of the G4-G6/actin complex.","URL":null,"raw_pages":"691-702","medline_journal":"J Mol Biol","ISO_journal":"J. Mol. Biol.","authors":["Choe H","Burtnick LD","Mejillano M","Yin HL","Robinson RC","Choe S."],"DOI_URL":"http://dx.doi.org/10.1016/S0022-2836(02)01131-2"},"PUB00000950":{"PMID":9288746,"ISBN":null,"volume":"90","issue":"4","year":1997,"title":"The crystal structure of plasma gelsolin: implications for actin severing, capping, and nucleation.","URL":null,"raw_pages":"661-70","medline_journal":"Cell","ISO_journal":"Cell","authors":["Burtnick LD","Koepf EK","Grimes J","Jones EY","Stuart DI","McLaughlin PJ","Robinson RC."],"DOI_URL":"http://dx.doi.org/10.1016/S0092-8674(00)80527-9"}},"set_info":{"accession":"CL0092","name":"ADF"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":43,"interactions":0,"matches":1056,"pathways":0,"proteins":1055,"proteomes":989,"sets":1,"structural_models":{"alphafold":166},"structures":0,"taxa":2323},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":118,"alignment:full":824},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}