{"metadata":{"accession":"PF25453","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR057220","hierarchy":null,"name":{"name":"Domain of unknown function (DUF7898)","short":"DUF7898"},"description":[{"text":"<p>This entry describes the N-terminal domain of unknown function of DNA polymerase theta subunit (PolQ) majoritarily from fungal and and yeast proteins. Structural predictions suggest that this family adopts Helix-Helix-Helix (HHH) motifs. Proteins containing HHH motifs are typically associated with DNA-binding functions. These structural elements are often found in enzymes involved in DNA metabolism, such as DNA polymerases and helicases [[cite:PUB00101275],[cite:PUB00021052]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00101275":{"PMID":26636256,"ISBN":null,"volume":"23","issue":"12","year":2015,"title":"Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway.","URL":null,"raw_pages":"2319-2330","medline_journal":"Structure","ISO_journal":"Structure","authors":["Newman JA","Cooper CDO","Aitkenhead H","Gileadi O."],"DOI_URL":null},"PUB00021052":{"PMID":10908318,"ISBN":null,"volume":"28","issue":"14","year":2000,"title":"Common fold in helix-hairpin-helix proteins.","URL":null,"raw_pages":"2643-50","medline_journal":"Nucleic Acids Res","ISO_journal":"Nucleic Acids Res.","authors":["Shao X","Grishin NV."],"DOI_URL":"http://dx.doi.org/10.1093/nar/28.14.2643"}},"set_info":{"accession":"CL0198","name":"HHH"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":52,"interactions":0,"matches":1406,"pathways":0,"proteins":1405,"proteomes":1148,"sets":1,"structural_models":{"alphafold":624},"structures":17,"taxa":2960},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":50,"alignment:full":1018},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}