This entry represents a domain of unknown function (DUF) identified in Trypanosoma. Based on structural predictions, this domain is hypothesised to adopt a winged helix-turn-helix (HTH) fold. Winged helix DNA-binding proteins share a characteristic winged helix-turn-helix DNA-binding motif, in which the \"wings\", or loops, are small beta-sheets [[cite:PUB00013195]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00013195":{"PMID":10679470,"ISBN":null,"volume":"10","issue":"1","year":2000,"title":"Winged helix proteins.","URL":null,"raw_pages":"110-6","medline_journal":"Curr Opin Struct Biol","ISO_journal":"Curr. Opin. Struct. Biol.","authors":["Gajiwala KS","Burley SK."],"DOI_URL":"http://dx.doi.org/10.1016/S0959-440X(99)00057-3"}},"set_info":{"accession":"CL0123","name":"HTH"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":27,"pathways":0,"proteins":27,"proteomes":27,"sets":1,"structural_models":{"alphafold":26},"structures":0,"taxa":62},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":7,"alignment:full":16},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}