This entry represents the C-terminal domain of unknown function found in Trypanosoma proteins. According to structure predictions it could adopt a DNA clamp fold.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00101311":{"PMID":12888511,"ISBN":null,"volume":"31","issue":"15","year":2003,"title":"Evolutionary clues to DNA polymerase III beta clamp structural mechanisms.","URL":null,"raw_pages":"4503-16","medline_journal":"Nucleic Acids Res","ISO_journal":"Nucleic Acids Res","authors":["Neuwald AF."],"DOI_URL":null}},"set_info":{"accession":"CL0060","name":"DNA_clamp"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":29,"pathways":0,"proteins":29,"proteomes":28,"sets":1,"structural_models":{"alphafold":27},"structures":0,"taxa":64},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":8,"alignment:full":18},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}