This entry represents a domain of unknown function. In some proteins the is a C-terminal HTH domain that presumably binds to DNA. This domain may bind to an as unyet identified ligand to enable regulation of bacterial genes. This domain contains a large beta sheet composed of 11 beta strands with helices packed on the convex face. There is some evidence from structure prediction that this domain may dimerise and form a large structure that has a large hole through it that might accommodate DNA.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":5,"interactions":0,"matches":291,"pathways":0,"proteins":289,"proteomes":194,"sets":0,"structural_models":{"alphafold":251},"structures":0,"taxa":350},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":60,"alignment:full":136},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}