This entry represents an uncharacterised bacterial protein domain. This domain is found in single domain proteins as well as in large multidomain proteins that contain immunity related domains. This suggests that this family may play a role in a toxin/antitoxin system. The domain contains two structural sites that contain two conserved histidines and an aspartate that may be functionally important.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":23,"interactions":0,"matches":639,"pathways":0,"proteins":639,"proteomes":594,"sets":0,"structural_models":{"alphafold":360},"structures":0,"taxa":1108},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":79,"alignment:full":280},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}