{"metadata":{"accession":"PF25127","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR056721","hierarchy":null,"name":{"name":"Domain of unknown function (DUF7819)","short":"DUF7819"},"description":[{"text":"<p>This domain is found towards the C-terminal end of human Calcium homeostasis endoplasmic reticulum protein (CHERP), which is involved in calcium homeostasis, growth and proliferation. This domain is usually found associated with [pfam:PF01585]. Its specific function is unknown. It shows highly conserved GWE and GLYE/DxY/F motifs.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":37,"interactions":0,"matches":1997,"pathways":0,"proteins":1994,"proteomes":1224,"sets":0,"structural_models":{"alphafold":1743},"structures":0,"taxa":3986},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":16,"alignment:full":1542},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}