{"metadata":{"accession":"PF25118","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR056752","hierarchy":null,"name":{"name":"Elongation factor-like GTPase 1-like domain","short":"EFL1"},"description":[{"text":"<p>This domain is found in human Elongation factor-like GTPase 1 (EFL1) and similar eukaryotic proteins. EFL1 is involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00100665":{"PMID":26912367,"ISBN":null,"volume":"351","issue":"6280","year":2016,"title":"Molecular architecture of the human U4/U6.U5 tri-snRNP.","URL":null,"raw_pages":"1416-20","medline_journal":"Science","ISO_journal":"Science","authors":["Agafonov DE","Kastner B","Dybkov O","Hofele RV","Liu WT","Urlaub H","Luhrmann R","Stark H."],"DOI_URL":null},"PUB00159893":{"PMID":26479198,"ISBN":null,"volume":"22","issue":"11","year":2015,"title":"Mechanism of eIF6 release from the nascent 60S ribosomal subunit.","URL":null,"raw_pages":"914-9","medline_journal":"Nat Struct Mol Biol","ISO_journal":"Nat Struct Mol Biol","authors":["Weis F","Giudice E","Churcher M","Jin L","Hilcenko C","Wong CC","Traynor D","Kay RR","Warren AJ."],"DOI_URL":"https://doi.org/10.1038/nsmb.3112"},"PUB00152086":{"PMID":33007253,"ISBN":null,"volume":"80","issue":"1","year":2020,"title":"Structural Insights into the Roles of Metazoan-Specific Splicing Factors in the Human Step 1 Spliceosome.","URL":null,"raw_pages":"127-139.e6","medline_journal":"Mol Cell","ISO_journal":"Mol Cell","authors":["Bertram K","El Ayoubi L","Dybkov O","Agafonov DE","Will CL","Hartmuth K","Urlaub H","Kastner B","Stark H","Luhrmann R."],"DOI_URL":"https://doi.org/10.1016/j.molcel.2020.09.012"}},"set_info":{"accession":"CL0329","name":"S5"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":90,"interactions":0,"matches":3996,"pathways":0,"proteins":3996,"proteomes":2607,"sets":1,"structural_models":{"alphafold":3467,"bfvd":0},"structures":2,"taxa":7334},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":168,"alignment:full":2587},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}