This domain is found in uncharacterised protein from Leptospira interrogans serogroup Icterohaemorrhagiae serovar Copenhageni and related bacterial proteins. Its structure was determined (PDB:6ULO) and shares a significant similarity to various methyltransferases.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0063","name":"NADP_Rossmann"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":154,"pathways":0,"proteins":144,"proteomes":99,"sets":1,"structural_models":{"alphafold":89},"structures":1,"taxa":204},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":21,"alignment:full":71},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"6ulo","name":"Structure of an N-terminally truncated uncharacterized protein from Leptospira interrogans serogroup Icterohaemorrhagiae serovar Copenhageni (strain Fiocruz L1-130)"}}}