This domain is found in uncharacterised protein ZK892.6 from Caenorhabditis elegans and related proteins. It is found either standalone or in combination with other domains. Some proteins contain multiple copies of this domain. It is predicted to adopt a globular structure consisting of an antiparallel six-stranded beta-sheet and alpha-helices packed on both sides of it. This domain contains a highly conserved PxxPP motif.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
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