This entry represents a group of uncharacterised prokaryotic proteins. They are likely to contain two domains that create a compact elongated structure. Toward the C terminus, these proteins have two highly conserved pairs of cysteines which are likely to be involved in metal coordination.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":178,"pathways":0,"proteins":178,"proteomes":172,"sets":0,"structural_models":{"alphafold":130},"structures":0,"taxa":339},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":66,"alignment:full":87},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}