This entry represents a domain found in uncharacterised bacterial proteins. It shares detectable similarity to a number of type II restriction endonucleases such as DpnII and Ecl18kI and it is predicted to adopt similar structure. It is likely to possess endonuclease activity given the conservation of putative functional site residues.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0236","name":"PDDEXK"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":52,"pathways":0,"proteins":52,"proteomes":50,"sets":1,"structural_models":{"alphafold":32},"structures":0,"taxa":187},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":22,"alignment:full":26},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}