This domain is found in uncharacterised bacterial proteins. It contains two pairs of conserved cysteine residues and it is predicted to adopt a fold typical for treble clef zinc fingers. It has a detectable similarity to the N-terminal zinc finger domain of the bacterial AAA+ disaggregase ClpG, which confers extreme heat resistance to bacteria. The latter is is crucial for structural integrity and disaggregase functionality of ClpG.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0839","name":"Tbcl_zf"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":6,"interactions":0,"matches":114,"pathways":0,"proteins":114,"proteomes":103,"sets":1,"structural_models":{"alphafold":69},"structures":0,"taxa":239},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":37,"alignment:full":62},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}