This entry represents an uncharacterised family of proteins, which are typically between 100 and 122 amino acids in length. This protein is often found to be plasmid borne and in a few cases is associated with ParBc domains that are critical for plasmid segregation. This suggests that this domain may play a role in chromosome segregation or plasmid partitioning. Structural modelling suggests this domain will form a homodimeric complex.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":513,"pathways":0,"proteins":512,"proteomes":421,"sets":0,"structural_models":{"alphafold":327},"structures":0,"taxa":769},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":135,"alignment:full":238},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}