This family of uncharacterised proteins is found in bacteria (Bacteroidota and Chloroflexi). Proteins in this family are approximately 80 amino acids in length. The proteins are likely to be integral membrane proteins with two transmembrane alpha helices. Structural modelling suggests that these proteins form a dimeric arrangement with the pairs of alpha helices tilted at close to 45 degrees angle compared to the lipid membrane. Based on the positive inside rule it is likely that the N and C-terminii of the proteins have a cytoplasmic location. Given the geometry of the protein complex it may not span the entire membrane.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
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