This domain is found in uncharacterised bacterial proteins. It is frequently found in combination with [pfam:PF21818] and [pfam:PF20815] which suggests that it may be involved in DNA binding and recognition. It is predicted to adopt a globular structure consisting of a three-stranded antiparallel beta-sheet and alpha-helices packed on one side of it.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":38,"interactions":0,"matches":730,"pathways":0,"proteins":730,"proteomes":663,"sets":0,"structural_models":{"alphafold":464},"structures":0,"taxa":1264},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":9,"alignment:full":355},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}