This domain is found in the Polycomb group protein EMBRYONIC FLOWER 2 (EMF2) from Arabidopsis thaliana and related proteins. EMF2 is involved in flowering processes by repressing unknown target genes and preventing reproductive development. This domain is predicted to adopt a globular structure that resembles barrel-sandwich hybrid. The beta-sandwich has a topology most similar to C2 domains found in diverse proteins such as CEP120, Dysferlin and Myoferlin.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00083743":{"PMID":18281509,"ISBN":null,"volume":"20","issue":"2","year":2008,"title":"EMBRYONIC FLOWER1 participates in polycomb group-mediated AG gene silencing in Arabidopsis.","URL":null,"raw_pages":"277-91","medline_journal":"Plant Cell","ISO_journal":"Plant Cell","authors":["Calonje M","Sanchez R","Chen L","Sung ZR."],"DOI_URL":"http://dx.doi.org/10.1105/tpc.106.049957"},"PUB00083742":{"PMID":19783648,"ISBN":null,"volume":"152","issue":"2","year":2010,"title":"Epigenetic regulation of gene programs by EMF1 and EMF2 in Arabidopsis.","URL":null,"raw_pages":"516-28","medline_journal":"Plant Physiol","ISO_journal":"Plant Physiol.","authors":["Kim SY","Zhu T","Sung ZR."],"DOI_URL":"http://dx.doi.org/10.1104/pp.109.143495"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":30,"interactions":0,"matches":1414,"pathways":0,"proteins":1391,"proteomes":363,"sets":0,"structural_models":{"alphafold":1144},"structures":0,"taxa":1046},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":86,"alignment:full":954},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}