This domain is found in uncharacterised bacterial proteins. It is usually associated with von Willebrand factor type A domain (e.g. [pfam:PF00092]), which is inserted into the domain core. Members of this entry are likely to contain an intramolecular isopeptide bond. The domain represented by this entry is predicted to fold into a beta-sandwich but does not include the two N-terminal strands that precede the von Willebrand factor type A domain.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0204","name":"Adhesin"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":60,"interactions":0,"matches":143,"pathways":0,"proteins":139,"proteomes":113,"sets":1,"structural_models":{"alphafold":77},"structures":3,"taxa":232},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":54,"alignment:full":89},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}