This entry represents a small family of uncharacterised proteins found in archaea and eukaryotes. These proteins contain two pairs of conserved cysteines and two pairs of conserved histidines that are probably involved in zinc coordination. These proteins likely resemble two classical C2H2 zinc fingers that pack on each other and form a compact globular structure.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0361","name":"C2H2-zf"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":10,"interactions":0,"matches":344,"pathways":0,"proteins":343,"proteomes":317,"sets":1,"structural_models":{"alphafold":325},"structures":0,"taxa":623},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":53,"alignment:full":185},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}