{"metadata":{"accession":"PF24346","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR055354","hierarchy":null,"name":{"name":"CLIPPER 2 domain","short":"CLIPPER_2"},"description":[{"text":"<p>This domain is found in multiple copies in a number of bacterial proteins. It is closely related to the CLIPPER domain ([pfam:PF01345]) and therefore it was named CLIPPER 2 (Cross-Linked IsoPeptide Protein in the Extracellular Region 2) [[cite:PUB00163642]]. Similarly to CLIPPER, this domain contains a conserved N-terminal lysine and a C-terminal asparagine with central aspartate/glutamate residues suggesting that it may contain an isopeptide bond. In addition, it contains a semi-conserved TNTGNV sequence motif in which a highly conserved asparagine probably plays a role in stabilising the rod structure formed by repetitive copies of this domain. Both CLIPPER and CLIPPER_2 domains are frequently found in tandem within surface polypeptides of bacteria and archaea, often alternating between the two families in tandem.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00163642":{"PMID":41236442,"ISBN":null,"volume":"34","issue":"12","year":2025,"title":"A global survey of intramolecular isopeptide bonds.","URL":null,"raw_pages":"e70342","medline_journal":"Protein Sci","ISO_journal":"Protein Sci","authors":["Costa F","Riziotis I","Andreeva A","Kalwan D","de Jong J","Hinchliffe P","Parmeggiani F","Race PR","Burston SG","Bateman A","Barringer R."],"DOI_URL":"https://doi.org/10.1002/pro.70342"}},"set_info":{"accession":"CL0159","name":"E-set"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1301,"interactions":0,"matches":15693,"pathways":0,"proteins":3311,"proteomes":1861,"sets":1,"structural_models":{"alphafold":1164},"structures":0,"taxa":3040},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":130,"alignment:full":8343},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}