This entry represents a domain consisting of a novel repeat fold which containing five repeats, each of them comprising three antiparallel beta-strands and a short alpha-helix, according to structure predictions (e.g SwissProt:S8CFV9). This domain is found in Casein kinase 1-like protein HD16 from rice, a protein involved in the regulation of flowering time through gibberellin (GA) signaling and independently of photoperiod [[cite:PUB00155615]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00155615":{"PMID":20400938,"ISBN":null,"volume":"29","issue":"11","year":2010,"title":"Rice early flowering1, a CKI, phosphorylates DELLA protein SLR1 to negatively regulate gibberellin signalling.","URL":null,"raw_pages":"1916-27","medline_journal":"EMBO J","ISO_journal":"EMBO J","authors":["Dai C","Xue HW."],"DOI_URL":"https://doi.org/10.1038/emboj.2010.75"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":97,"interactions":0,"matches":4215,"pathways":0,"proteins":4059,"proteomes":496,"sets":0,"structural_models":{"alphafold":3285},"structures":0,"taxa":1395},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":17,"alignment:full":2790},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}