This entry represents an uncharacterized family found in various bacteriophage proteins. It is predominantly found in phages infecting diverse bacterial species including Burkholderia, Bacillus, Streptomyces, Listeria, and Caulobacter. The proteins are typically around 100-150 amino acids in length. Many of the proteins containing this domain are annotated as uncharacterized or hypothetical proteins. The proteins form a compact domain composed of a four stranded antiparallel beta sheet.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
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