This entry represents a highly conserved domain found in various bacteriophages, particularly those infecting Salmonella and related bacteria. The domain is also present in some bacterial species, suggesting possible horizontal gene transfer. The function is unknown, but the high degree of conservation implies an important role in phage biology. A conserved motif DVT is present centrally in many family members. The aspartate and threonine form side chain hydrogen bonds that help stabilise the dimeric interaction. Structure prediction suggests these proteins form a confident homodimer (iPTM=0.83).
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
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