This entry represents a conserved domain found predominantly in bacteriophage proteins. The domain is characterized by a highly conserved YDRH motif, which likely plays an important role in the domain's function or structure. This family includes proteins from various phages that infect cyanobacteria, particularly Synechococcus and Prochlorococcus species. The proteins contain a central small domain composed of a three stranded beta sheet with an alpha helix inserted between the second and third strands.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":34,"pathways":0,"proteins":34,"proteomes":34,"sets":0,"structural_models":{"alphafold":3},"structures":0,"taxa":111},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":13,"alignment:full":23},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}