This entry represents a protein family of unknown function found in various bacterial phage proteins. The family typically consists of proteins around 140-160 amino acids in length. It is found in phages that infect bacteria such as Salmonella, Escherichia, Shigella, and Dickeya. The function of this family remains unclear. Some members of this family are annotated as uncharacterized or hypothetical proteins. AlphaFold predictions suggest the proteins in this family contain two distinct domains, with a central domain composed of a three stranded beta sheet and a C-terminal small 3-helix bundle domain.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":61,"pathways":0,"proteins":61,"proteomes":60,"sets":0,"structural_models":{"alphafold":6},"structures":0,"taxa":141},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":6,"alignment:full":21},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}