This entry represents a family of uncharacterized proteins found in bacteriophages. The function of this protein family is currently unknown. The family appears to be conserved across various phage species that infect Escherichia coli and related bacteria. The family includes members from Phage T2, T4 and T6. Members of this family are typically short proteins of around 60-67 amino acids in length. Bacteriophage T4 contains four proteins that belong to this family. The structure of these proteins is predicted to be composed of two alpha helices that pack together. Structure prediction suggests these proteins may homodimerise (iPTM=0.83).
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
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