This entry represents a domain of unknown function found in bacteriophage proteins. The domain is around 90-95 amino acids in length. It is found in uncharacterized proteins from phages that infect Enterobacteria such as Salmonella and Shigella species as well as Dickeya. The specific function of this domain remains unknown. Structure prediction suggests that these proteins may form a homotetramer (iPTM=0.88). The domain contains a three twisted stranded beta sheet.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":44,"pathways":0,"proteins":44,"proteomes":43,"sets":0,"structural_models":{"alphafold":4},"structures":0,"taxa":99},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":2,"alignment:full":9},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}