This entry represents an uncharacterized protein domain found in various phage and bacterial proteins. The domain is approximately 60-80 amino acids in length. The domain is composed of four alpha helices that form a small bundle. The surface of the domain is negatively charged.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":50,"pathways":0,"proteins":50,"proteomes":50,"sets":0,"structural_models":{"alphafold":5},"structures":0,"taxa":136},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":15,"alignment:full":37},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}