This entry represents a protein of unknown function, found primarily in phage proteins of about 60 to 75 amino acids in length. It contains a single predicted transmembrane helix in many members. Most sequences also contain a region of predicted intrinsic disorder at the C-terminus rich in basic and acidic residues. Further experimental study is required to determine the function of these proteins. Some proteins are annotated as holins but the source of this annotation is unknown.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":33,"pathways":0,"proteins":33,"proteomes":33,"sets":0,"structural_models":{"alphafold":5},"structures":0,"taxa":94},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":7,"alignment:full":31},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}