This domain is found in uncharacterised plant proteins. It is predicted to adopt an alpha/beta structure with a central four-stranded antiparallel beta-sheet and alpha helices packed on it. It has weak sequence and structural similarity to NIL domains. It is usually found N-terminal to protein kinase domains.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0070","name":"ACT"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":17,"interactions":0,"matches":627,"pathways":0,"proteins":624,"proteomes":351,"sets":1,"structural_models":{"alphafold":502},"structures":0,"taxa":961},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":55,"alignment:full":394},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}