{"metadata":{"accession":"PF23913","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR055679","hierarchy":null,"name":{"name":"Family of unknown function (DUF7255)","short":"DUF7255"},"description":[{"text":"<p>This entry represents uncharacterised bacterial proteins that were predicted to possess defence functions [[cite:PUB00152882]]. They contain highly conserved aspartate and histidine residues that may have functional role.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00152882":{"PMID":32855333,"ISBN":null,"volume":"369","issue":"6507","year":2020,"title":"Diverse enzymatic activities mediate antiviral immunity in prokaryotes.","URL":null,"raw_pages":"1077-1084","medline_journal":"Science","ISO_journal":"Science","authors":["Gao L","Altae-Tran H","Bohning F","Makarova KS","Segel M","Schmid-Burgk JL","Koob J","Wolf YI","Koonin EV","Zhang F."],"DOI_URL":"https://doi.org/10.1126/science.aba0372"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":155,"pathways":0,"proteins":155,"proteomes":150,"sets":0,"structural_models":{"alphafold":98},"structures":0,"taxa":275},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":40,"alignment:full":59},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}