This entry represents an uncharacterized protein domain found in viral proteins, primarily from Mycobacterium and Gordonia phages. The domain is approximately 120 amino acids in length. These proteins are composed of a small N-terminal zinc binding domain connected by an alpha helix to a small beta barrel domain at the C-terminus.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":27,"pathways":0,"proteins":27,"proteomes":27,"sets":0,"structural_models":{"alphafold":2},"structures":0,"taxa":78},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":6,"alignment:full":11},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}