This entry represents a family of uncharacterized proteins found in phage and bacterial species, particularly in the Gammaproteobacteria class. Members of this family are typically short proteins, ranging from 32 to 85 amino acids in length. Many members are predicted to contain disordered regions and AlphaFold predictions show a non-globular structure.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
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