This domain is found in uncharacterised proteins. It is usually found in combination with [[pfam:PF22515]] and [[pfam:PF22518]]. It is predicted to contain a winged helix (WH) domain that is flanked at the C terminus with a small helical subdomain. The latter packs on the WH domain to form a compact globular structure.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0123","name":"HTH"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":13,"interactions":0,"matches":300,"pathways":0,"proteins":293,"proteomes":282,"sets":1,"structural_models":{"alphafold":205},"structures":0,"taxa":803},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":68,"alignment:full":179},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}