This entry represents a domain of unknown function found in phage proteins, typically 45-60 amino acids in length. It is found in Streptomyces phages of the Caudoviricetes order, primarily in the Arquatrovirinae subfamily. The domain does not contain any conserved motifs or residues that provide hints about its function. A structure prediction shows that it is composed of two non-interacting alpha helices.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":44,"pathways":0,"proteins":44,"proteomes":44,"sets":0,"structural_models":{"alphafold":7},"structures":0,"taxa":116},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":9,"alignment:full":28},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}