This entry represents a family of phage proteins that adopt a small beta barrel-like domain. The family is found in phages infecting members of the Enterobacteriaceae, such as Escherichia, Salmonella, Klebsiella, Cronobacter, Citrobacter, Erwinia, and Pectobacterium. The exact function of this protein within the phage tail is unknown. The family shows a highly conserved length of around 60-75 amino acids, with a few members having N- or C-terminal extensions.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0010","name":"SH3"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":343,"pathways":0,"proteins":343,"proteomes":318,"sets":1,"structural_models":{"alphafold":57},"structures":0,"taxa":806},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":47,"alignment:full":157},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}