This domain family is found in viruses that infect Streptococcus thermophilus bacteria. All members are from Caudoviricetes viruses. The domain is approximately 50 amino acids in length. The function of this domain is currently unknown. An AlphaFold model shows these proteins adopt a compact domain composed of a three stranded beta sheet with a single alpha helix.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
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