This entry represents an uncharacterized protein found in various phages that infect bacteria including Escherichia, Salmonella, Shigella, Klebsiella, Enterobacter, Citrobacter and Cronobacter. The protein ranges in length from around 66 to 98 amino acids. The protein forms a single compact domain composed of a four stranded beta sheet and two alpha helices. The structure shows some weak structural similarity to the BRICHOS domain. No clear function is known for these proteins.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":133,"pathways":0,"proteins":133,"proteomes":128,"sets":0,"structural_models":{"alphafold":3},"structures":0,"taxa":280},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":11,"alignment:full":20},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}