This entry represents a bacterial domain of unknown function. The domain is around 270 to 300 amino acids in length. It is found in a variety of bacterial phyla including Actinobacteria, Bacteroidota, Pseudomonadota and Verrucomicrobiota. The domain is also found in some bacterial phages. The function of this domain is unknown. The structure of this domain shows similarity to VWFA domains.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0128","name":"vWA-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":181,"pathways":0,"proteins":181,"proteomes":154,"sets":1,"structural_models":{"alphafold":60},"structures":0,"taxa":383},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":46,"alignment:full":89},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}