This entry represents an uncharacterized protein domain found in phage, predominantly those infecting bacteria in the Enterobacteriaceae family such as Escherichia, Salmonella, Klebsiella and Vibrio. The protein is typically around 80 to 100 amino acids in length. In some phage the protein contains a predicted central coiled-coil region. The function of this protein family is currently unknown.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
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