This entry represents a domain found in proteins typically around 200 amino acids in length. It is found in phage that infect Mycobacteria, Gordonia, and Nocardia. The exact function is unknown. The structure of the domain shows an extended beta sandwich fold where one sheet is hinged in the middle to form a kink.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":161,"pathways":0,"proteins":161,"proteomes":64,"sets":0,"structural_models":{"alphafold":42},"structures":0,"taxa":151},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":49,"alignment:full":120},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}