This domain family consists of a group of uncharacterized proteins, typically between 99 to 116 amino acids in length, found in bacteriophages that infect Microbacterium and Arthrobacter bacterial hosts. These proteins are encoded in the genomes of phages belonging to the Caudoviricetes class, primarily within the families Azeevirinae, Dismasvirus, Yangvirus, Manhattanvirus, Liebevirus, Zetavirus, and Armstrongvirus. An AlphaFold prediction shows these proteins are composed of two alpha helices. AlphaFold also predicts that these proteins likely form homodimers.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
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