{"metadata":{"accession":"PF23767","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR055590","hierarchy":null,"name":{"name":"TscA antitoxin","short":"TscA"},"description":[{"text":"<p>This protein domain is found in a variety of staphylococcus phage proteins. It was shown to be the antitoxin TscA of a toxin-antitoxin system [[cite:PUB00159162]], with TscT being the toxin [pfam:PF07342]. It is composed of two alpha helices and a beta hairpin and shows weak structural similarity to archaeal prefoldins. Members of this family form a confident homodimer structure with AlphaFold 3 (A0A0H3JR29 iPTM=0.81).</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00159162":{"PMID":31375497,"ISBN":null,"volume":"85","issue":"20","year":2019,"title":"Genome-Wide Screening for Identification of Novel Toxin-Antitoxin Systems in Staphylococcus aureus.","URL":null,"raw_pages":"e00915-19","medline_journal":"Appl Environ Microbiol","ISO_journal":"Appl Environ Microbiol","authors":["Kato F","Yoshizumi S","Yamaguchi Y","Inouye M."],"DOI_URL":"https://doi.org/10.1128/AEM.00915-19"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":48,"pathways":0,"proteins":48,"proteomes":37,"sets":0,"structural_models":{"alphafold":24},"structures":0,"taxa":78},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":4,"alignment:full":16},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}