This domain is found in plant proteins that are probably related to NOMO family of proteins. The latter are components of the multi-pass translocon (MPT) complex which mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes [[cite:PUB00155613]]. The domain represented by this entry is predicted to adopt a globular beta-sandwich structure with a prealbumin-like topology.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00155613":{"PMID":6261522,"ISBN":null,"volume":"7","issue":null,"year":1981,"title":"The fine structure of cells in astrocytomas of various grades of malignancy.","URL":null,"raw_pages":"88-90","medline_journal":"Acta Neuropathol Suppl","ISO_journal":"Acta Neuropathol Suppl","authors":["Ebhardt G","Cervos-Navarro J."],"DOI_URL":"https://doi.org/10.1007/978-3-642-81553-9_27"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":100,"interactions":0,"matches":627,"pathways":0,"proteins":627,"proteomes":343,"sets":0,"structural_models":{"alphafold":514},"structures":0,"taxa":1096},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":59,"alignment:full":375},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}