{"metadata":{"accession":"PF23653","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR055573","hierarchy":null,"name":{"name":"Domain of unknown function (DUF7149)","short":"DUF7149"},"description":[{"text":"<p>This domain is found in related bacterial proteins. It is predicted to adopt an alpha/beta globular structure and shares significant sequence and structural similarity to members of PD-(D/E)XK nuclease superfamily, in particular, BpuSI N-terminal nuclease domain ([pfam:PF15516]).</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0236","name":"PDDEXK"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":17,"interactions":0,"matches":421,"pathways":0,"proteins":418,"proteomes":357,"sets":1,"structural_models":{"alphafold":236},"structures":0,"taxa":724},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":102,"alignment:full":214},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}