This domain of unknown function is found N-terminal in a group of uncharacterised proteins mainly from plants. This domain is predicted to adopt a beta-barrel with topology typical for PH domains. It has a weak sequence similarity to Dcp1 PH domain.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0266","name":"PH"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":22,"interactions":0,"matches":1097,"pathways":0,"proteins":1090,"proteomes":413,"sets":1,"structural_models":{"alphafold":870},"structures":0,"taxa":1122},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":123,"alignment:full":690},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}