This entry is a domain of unknown function found in some PA-PLA1 family members, which consists of mitochondrial proteins that are probable phospholipases with a specific function to hydrolyze phosphatidic acid. Members of this family are involved in the metabolism of phospholipids, which are critical components of cell membranes. By hydrolyzing phosphatidic acid, these enzymes may play a role in the regulation of mitochondrial membrane composition and dynamics, as well as in signaling pathways related to lipid metabolism.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
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