This domain is found in a group of uncharacterised proteins mainly from Halobacteria. It contains highly conserved cysteine residues arranged in two CxxC motifs that likely coordinate zinc. The first motif could be more broadly defined as a semi-conserved MWRCxxCGEM sequence motif. This domain is predicted to adopt a zinc ribbon fold with similarity to rubredoxin-like domains.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0167","name":"Zn_Beta_Ribbon"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":383,"pathways":0,"proteins":383,"proteomes":247,"sets":1,"structural_models":{"alphafold":355},"structures":0,"taxa":402},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":45,"alignment:full":133},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}