This domain is found in a group of small proteins mainly from Halobacteria. It contains highly conserved cysteine and histidine residues arranged in two CxxC and HxxC motifs that likely coordinate zinc. This domain is predicted to adopt a fold similar to the classical C2H2 and variant C2HC zinc fingers containing beta-hairpin and an alpha helix. In addition, it is predicted to contain an extra N-terminal strand that contributes to the formation of a three-stranded antiparallel beta-sheet. This domain also has a number of highly conserved negatively charged residues.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0361","name":"C2H2-zf"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":176,"pathways":0,"proteins":176,"proteomes":175,"sets":1,"structural_models":{"alphafold":170},"structures":0,"taxa":342},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":47,"alignment:full":62},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}