This domain is found in uncharacterised proteins mainly from fungi. This domain is predicted to adopt a globular structure consisting of a four helical bundle and having structural similarity to the alpha-helical domain inserted in the third Ig domain of the Trs130 component of the TRAPPII complex [[cite:PUB00153720]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00153720":{"PMID":35080977,"ISBN":null,"volume":"8","issue":"4","year":2022,"title":"Structural basis for assembly of TRAPPII complex and specific activation of GTPase Ypt31/32.","URL":null,"raw_pages":"eabi5603","medline_journal":"Sci Adv","ISO_journal":"Sci Adv","authors":["Mi C","Zhang L","Huang G","Shao G","Yang F","You X","Dong MQ","Sun S","Sui SF."],"DOI_URL":"https://doi.org/10.1126/sciadv.abi5603"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":8,"interactions":0,"matches":49,"pathways":0,"proteins":49,"proteomes":48,"sets":0,"structural_models":{"alphafold":40},"structures":0,"taxa":119},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":26,"alignment:full":37},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}